Bacterial tyrosine kinases: evolution, biological function and structural insights
نویسندگان
چکیده
منابع مشابه
Bacterial tyrosine kinases: evolution, biological function and structural insights.
Reversible protein phosphorylation is a major mechanism in the regulation of fundamental signalling events in all living organisms. Bacteria have been shown to possess a versatile repertoire of protein kinases, including histidine and aspartic acid kinases, serine/threonine kinases, and more recently tyrosine and arginine kinases. Tyrosine phosphorylation is today recognized as a key regulatory...
متن کاملBacterial Protein-Tyrosine Kinases
Bacteria and Eukarya share essentially the same family of protein-serine/threonine kinases, also known as the Hanks-type kinases. However, when it comes to protein-tyrosine phosphorylation, bacteria seem to have gone their own way. Bacterial protein-tyrosine kinases (BY-kinases) are bacterial enzymes that are unique in exploiting the ATP/GTPbinding Walker motif to catalyze phosphorylation of pr...
متن کاملEvolution of Receptor Tyrosine Kinases
Receptor tyrosine kinases (RTKs) are important molecules for communication of cells in multicellular animals. It is therefore not surprising that the basal metazoans, like Hydra and sponges, already have a well-developed repertoire of RTKs. Even the choanofl agellate Monosiga brevicollis , a unicellular eukaryote from a group of protozoa that are thought to represent the ancestors of metazoa or...
متن کاملEvolution of Bacterial Protein-Tyrosine Kinases and Their Relaxed Specificity Toward Substrates
It has often been speculated that bacterial protein-tyrosine kinases (BY-kinases) evolve rapidly and maintain relaxed substrate specificity to quickly adopt new substrates when evolutionary pressure in that direction arises. Here, we report a phylogenomic and biochemical analysis of BY-kinases, and their relationship to substrates aimed to validate this hypothesis. Our results suggest that BY-k...
متن کاملProtein-serine/threonine/tyrosine kinases in bacterial signaling and regulation.
In this review, we address some recent developments in the field of bacterial protein phosphorylation, focusing specifically on serine/threonine and tyrosine kinases. We present an overview of recent studies outlining the scope of physiological processes that are regulated by phosphorylation, ranging from cell cycle, growth, cell morphology, to metabolism, developmental phenomena, and virulence...
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ژورنال
عنوان ژورنال: Philosophical Transactions of the Royal Society B: Biological Sciences
سال: 2012
ISSN: 0962-8436,1471-2970
DOI: 10.1098/rstb.2011.0424